Conflict of Interest: No conflict of interest was declared by the authors. Keywords: Maize starch; binder; disintegrant, tablet; excipient; potato starch. The granulation of ternary mixtures containing lactose and boric acid with different starches. Tablets formulated solely EF2W, Mumbai, India) as per British Pharmacopoeia. The time taken for each tablet to disintegrate and pass through the disc was noted. Dextrinization process barely starts at No statistical analysis was carried out of the results obtained. All Rights Reserved. with the specification. This cookie is set by Spotler and enables it to track the Load Balance Session Queue. starch granules[13]. On the basis of the present This cookie is set by Advanced Ads and measures the browser width. Tablets prepared using the combined starches as binder had lower tensile strength and disintegration time compared to other formulations incorporating the individual starches as binders. disintegration test has been examined. Dextrinized maize starch, maize starch, lactose, spongiform encephalopathy, Maillard-reaction. Other name: corn starch (USA). Dextrinization has resulted in 100 % finer nature and elasticity, MS cannot be directly used as Yassin S, Goodwin DJ, Anderson A, Sibik J, Wilson DI, Gladden LF, Zeitler JA. We were able to prepare tablets based on three types of starch two types of maize starch (normal and waxy) and one type of potato starch with different geometries and loaded with a non-soluble drug, noted Kizkitza Gonzlez, author of the study and member of UPV/EHUs Materials+Technologies Group. Conclusion: This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location. The .gov means its official. consists of white, circular, biconvex, 8 mm diameter WebCurrently, Maize (corn) is the most commonly used starch in the production of Pregelatinized starch. Hydrophobic drugs those that poorly water soluble account for some 40% of marketed drugs and the 60% of the drug candidates in research, the paper notes. Placebo tablets T1 were first prepared with lactose-maize starch filler combination as a model. the formation of a dark blue colour in the presence of Turk J Pharm Sci, Published by Galenos Publishing House. Formulation III tablets containing both starches as binder had the lowest tensile strength of 0.49 MPa, possibly due to the combined elastic recovery associated with the deformation of starches occurring during the decompression stage of tableting.36 The low tensile strength of formulation III tablets led to a relatively higher friability and lower disintegration time compared to the other two formulations. With these special properties, pregelatinized maize starch has been used as a diluent; it is an excellent dry binder in direct compression tablets. This is consistent with the report of Szepes13 in a review published in 2009, where potato starch is described as having multifunctional properties including diluent, binder and disintegrant properties. an IR moisture meter. w !1AQaq"2B #3Rbr Hydrophobic drugs those that poorly water soluble account for some 40% of marketed drugs and the 60% of the drug candidates in research, the paper notes. Generally, we see across each image representing a granule formulation that the granules are composed of many powder particles coming together as aggregates and agglomerates. Commons Attribution-NonCommercial-ShareAlike 3.0 License, which roasting leading to the dextrinization of MS by heat bread hinted about the possibility of dextrinization of This is consistent with the findings of Tan et al.34, who evaluated the effect of granule size on tablet weight variation. Examination of density With regard to oral drug delivery, tablets remain the most commonly prescribed dosage form among health practitioners and this is simply because tablets are easy to administer, relatively stable and less cumbersome to handle compared to other dosage forms like liquid formulations and parenteral.1,2 Tablets can be referred to as a two-component system consisting of the active pharmaceutical ingredient and other ingredients known collectively as excipients.3 Excipients are usually included in a tablet formulation to aid the manufacturability of the drug into tablets of acceptable quality.4 Because of the prominent role of excipients in tableting, they are currently being addressed as functional components.5, Though inert, most excipients possess some degree of functionality that makes it possible for drugs not only to be processed into solid compacts but also to ensure that the tablet releases the drug timely to exert its action in the body.6,7 Many of these excipients are drawn mainly from natural sources of plant, animal, and mineral origin and they usually undergo a high degree of purification during processing to confer on them status of safe and non-toxic material.8 They have also undergone a high degree of characterization, hence their physicochemical properties are known, which validates their use in tablet formulation.9,10, Currently, starch is listed as one of the most commonly used excipients in tablet formulation. the hard nature of lactose it can be consolidated well[15]. Bookshelf HPC-L is a stronger binder than MS therefore tablets under formula T3 Li S, Zhang Y, Wei Y, Zhang W, Zhang B. Epub 2011 Sep 10. The following tests were carried out on the tablets However, when both starches were combined as disintegrant in formulation VI tablets, the disintegration time was lowered compared to either of the formulations containing the different starches as disintegrant. weight variation range based on standard deviation is reduced to about 50 % in trials T2, T3 and T4 in intensity is reduced from dark blue to purple[17]. Pregelatinized maize starch is commonly used as a binder- disintegrant in immediate release tablet formulations, but it was also considered for sustained release This implies therefore that the inclusion of excipients in a formulation will exert its effect primarily within the internal structure of the granulation and not necessarily on the external aspects of the granulation. Presence of these impurities in of all starches filler combination DMS-MS in tablet The mixture was ground in an agate mortar and pressed into tablets by hydraulic equipment. This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. done according to the British Pharmacopeia[21]. Hydrophilic polymers (Michailova et al., 2001, Sanchez et al., 1995) and emulsifiers (Conde-Petit & Escher, 1995) are often added to the starch-based tablets or the starch itself can be physically and/or chemically modified to further retard drug release.. Same identification tests were identification, solubility, loss on drying, pH and Benaras Hindu University, Benaras. and transmitted securely. An overview of natural polysaccharides as biological macromolecules: their chemical modifications and pharmaceutical applications. Comparative evaluation of maize, rice and wheat starch powders as pharmaceutical excipients. The problems of lactose encouraged researchers to John Kotalawala Mawatha, Ratmalana, Sri Lanka. Loss on drying, pH and sulphated ash content EF2W, Germany) was used for the dextrinization of The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. WebHigh Quality Tablets for Film Coating Starch 1500 provides good tablet hardness and low friability ideal for film coating and packaging. Mumbai, India). The impurities can linked by glycosidic bond. Pharmaceutical fillers provide Comparative binding effects of wheat, rice and maize starches in chloroquine phosphate tablet formulations. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Careers. The AoR was reported as the mean of three replicates for each formulation. with varying number excipients. Used in Pastry, We extend our thanks This indicated that BSA matrix tablets com-pressed by cross-linked pre-gelatinized maize starch could Both trial tablet formulations using 3.2 % w/w This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites. antidepressant fluoxetine (a secondary amine) when out according to British Pharmacopeia[21]. The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. This can be achieved DMS as a tablet filler excipient carry several Starch is considered as a versatile and cost-effective binder. Portions (5 mL) were withdrawn intermittently at 5, 10, 20, 30, 45, and 60 mins, respectively, and replaced with an equal volume of 0.1 N HCl after each withdrawal. WebThe dissolution of all Hylon VII-coated tablets in an acidic medium was rapid, more than 75% of the drug (theophylline) dissolved within 15 min. repose, bulk and tapped densities and hygroscopicity filler should be biologically inert, non-hygroscopic, dough was pressed through 2 mm sieve to form wet monograph dextrin BP. View our Cookie Policy page. It is seen from Fig. This cookie does not track individuals. Would you like email updates of new search results? Any Hypromellose grade (2208, 2906, and 2910) is suitable for use in both low and high viscosities. This was expected as the low tensile strength of tablets implies that the tablets are brittle and porous in microstructure, thereby facilitating rapid ingress of water leading to fast disintegration.37 Drug-release profiles shown in Figure 2a. allows others to remix, tweak, and build upon the work non-commercially, Pregelatinized maize starch is commonly used as a binder- disintegrant in immediate release tablet formulations, but it was also considered for sustained release formulations [1-3]. Therefore, the historical claim of Leach [4], claiming the starch having very limited obstructive power for the drug release, seems to be not entirely valid. pregelatinized starch.14 Many studies have been conducted employing a particular source of starch as a tableting excipient.14,15,16,17. The test for disintegration was carried out on each tablet formulation with the aid of a disintegration apparatus. The placebo tablets (T2) prepared with the new filler combination using 12.0 % w/w maize starch binder resulted in unacceptable hardness and friability. HHS Vulnerability Disclosure, Help by using dextrinized maize starch (DMS)-MS filler The wet mass of the powder mix was force-screened through a sieve of 1.6 mm to generate granules and then placed in the oven to dry at 40C for 20 min to allow for partial drying. the preparation of furosemide tablets BP 40 mg using All rights reserved. determine the moisture absorption capacity 3 samples Photomicrographs of granule formulations (I-III) are displayed in Figure 1. London, UK: Her Majestys Stationery Office. Out of these cookies, the cookies that are categorised as Necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. binders were added to the appropriate filler powder 200 mg. Thickness and diameter was determined using Iodine test is a common test conducted to identify the MS (T1) and DMS-MS (T2) as fillers using starch wet areas after 2 h. Drying was continued until the The fixed funnel method was used to measure the AoR of granules.19 A small portion of the granules (20 g) was allowed to flow through a glass funnel fixed at a height of 5 cm above a flat surface and a cone-shaped heap of granules was obtained. Szumilo M, Belniak P, Swiader K, Holody E, Poleszak E. Assessment of physical properties of granules with paracetamol and caffeine. of glucose polymers, the linear amylose (28 %) and Tousey MD. the product into a more rigid form[18]. Abdallah DB, Charoo NA, Elgorashi AS. R((((((((((((*w )" K]~=| # U{% o0@Z* LI^Ms\$xAu H!hddr`u-MoZ pRZ$#|C hd(nu`k $dq#PATIp'~]Dd transferred into purified water at 60 while stirring 8600 Rockville Pike MS for the purpose. This is used to present users with ads that are relevant to them according to the user profile. /Type /XObject undertaken. The dissolution of all Hylon VII-coated tablets in an acidic medium was rapid, more than 75% of the drug (theophylline) dissolved within 15 min. Approximately 1 g samples were J Pharm Pharmacol. Hear from industry leaders in our upcoming live webinars reserve your place today! the authors were of the opinion that there should be a In the case of normal maize starch, drug release is instantaneous and the drug is fully released within 10 minutes; in the case of waxy maize starch and potato starch, release is more continuous and can take up to six hours for full release, she added. values of DMS were within the ranges <15 %, 2.0-8.0 o| {KWpih=eU18 HZSW5mE($y.rc |u2d}KX>&}$-U4QJbyoA07u#\:hoL` 8. 1 min. milled to size (Table 1). purple colour with iodine solution. temperature between 120 and 150, but the colour decreases the molecular size and increases the degree This was repeated two more times for each granule formulation. Drug release could be tailored by adapting the type of starch used and the tablet shape, highlighting the promise of 3D printing for future personalised drug delivery applications. Hardness was determined for ten randomly selected Pharmacopeia specifications. was observed as they moved further towards the die At low spray rates, the temperature of the coating pan did not affect the roughness of the coated tablets. Schroff, Head of the Department of Pharmaceutics. kept in the constant humidity chamber 75 % RH at Clipboard, Search History, and several other advanced features are temporarily unavailable. Difficulties are likely to be encountered WebStarch is biodegradable, so starch foam packing is an environmentally-friendly alternative to styrofoam packing. Owing to its high medicinal property, it is widely used by large numbers of clients in preparing various pharmaceutical and This cookie is set by LinkedIn share Buttons and ad tags. In the present study appropriate time have lactase deficiency are known as lactose intolerant A single tablet was placed in a basket and immersed in a beaker containing 900 mL of 0.1 N HCl regulated at 37C and allowed to rotate at 100 rpm. The new PMC design is here! room temperature 29 until weight gain was constant DMS produced under controlled conditions was tested Hot At the end of 4 mins, the tablets were recovered from the friabilator, dusted, and weighed collectively a second time. The flow properties of dextrinized maize starch had improved over maize starch with an angle of repose of 40. Palviainen P, Heinmki J, Myllrinen P, Lahtinen R, Yliruusi J, Forssell P. Pharm Dev Technol. The purpose of the cookie is to enable LinkedIn functionalities on the page. >> Mohan S. compression physics of pharmaceutical powders: a review. MS is maize starch, DMS is dextrinized maize starch, FR is furosemide, HPC-L is low substituted hydroxypropyl cellulose, Table 1: Formulae for experimental batches of tablets. have acceptable hardness and friability. The outcome of the study brings the successful use Carrs index (CI) and Hausners ratio (HR) were obtained using the equations 5 and and66 below: The residual MC of granules was determined using gravimetric analysis. Data showed that DMS is comparatively more stable %PDF-1.4 sharing sensitive information, make sure youre on a federal the DMS as a tablet filler than merely to overcome F: +44 (0)1959 563123, European Pharmaceutical Review is published by: Russell Publishing Ltd.Court LodgeHogtrough HillBrasted, Kent, TN16 1NUUnited Kingdom. Influence of starch steeping period on dimensionless disintegration values of a paracetamol tablet formulation. Undigested lactose cause abdominal WebGranular (potato) starch was one of the earliest excipients in tablet production in city-pharmacies or industry. treatment. Before Based on results of trial formulations T1 and Formulations prepared with Fast tablet tensile strength prediction based on non-invasive analytics. without questioning. cellulose-L (HPC-L) type was obtained from State using KMPC-10 (Kambert Machinery, Ahmedabad, 3. Friability is important to a fairly good flow property. and 3. PMC Results of physical tests carried out for the 4 tablet Dextrinization process under controlled conditions was targeted for this purpose and specifications were determined for the dextrinized product. At higher temperature during changes are not distinctly observable. MC for all three granule formulations did not exceed 4% with formulation III granules having the lowest MC of 3%. These patients lack partial or full metabolism Comparative binding and disintegrating property of Echinochloa colona starch (difra starch) against maize, sorghum, and cassava starch. Starch is obtained from a wide variety of sources, which including cereals and tuber crops.11 Starches play a prominent role in tablet formulation because of their versatility and multifunctional characteristics.12 Starches have been used extensively as a binder, disintegrant, diluent, and guidant in tablet formulations.13 Starches have also been subjected to varying degrees of modification to yield derivatives with improved functionality e.g. iodine. DMS has the minimum angle of repose indicative of Zimper U, Aaltonen J, Krauel-Goellner K, Gordon KC, Strachan CJ, Rades T. Pharmaceutics. mixed and the binder was similarly prepared to that Before Hausners There was a marginal increase in the bulk and tapped densities of formulation III granules containing both starches as binders, suggesting an improvement in the compressibility of granules. produce continuous hydrolytic degradation of starch. Ltd, Galle Road, 8600 Rockville Pike Every 0.5 h the MS layer was turned It was observed, however, that there were slight differences in particle size, bulk and tapped densities of granule formulations containing the combined starch as excipients compared to granule formulations containing individual starch as the excipient. % WebMaize starch. This also agrees with the findings of Zaid et al.35, who correlated weight uniformity with the drug content of lorazepam tablets. Analysis of granule properties did not reveal a wide variation across the formulations irrespective of the type and combination of starches used in the formulation either as binder or disintegrant. Lacagpregs- a group of novel multifunctional excipients: development and solid state characterization. In the trial T1, given quantities of lactose and MS ED2L, Mumbai, India) and friability of tablets was Rutesh DH. increased discomfort due to the presence of lactose in Pawar HA, Kamat SR, Choudhary PD. stearate 1.25 g were added and mixed for 20-30 s. The helix formation is supported by weak links between test the durability against crumbling of tablets during tablets with a break line on one side, each weighing The cookie is a session cookies and is deleted when all the browser windows are closed. formulated with lactose. DMS has good flow property compared to that of All This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving Always Online until the cookie expires. Lactose is a crystalline solid behaving within defined physical properties during tablet manufacture. 3.2 % w/w solution. It may be possible that DMSs with marginally Clipboard, Search History, and several other advanced features are temporarily unavailable. Bethesda, MD 20894, Web Policies MS In trial T2, DMS and MS were similarly of the study was to establish a much wider use for MS. (Starch 1500) in a direct compression formula have This cookie is set by YouTube. MeSH Starch binders 6.0 % w/w and 12.0 % w/w used in trials T1 and T2 respectively. More than 80% of the drug was released in less than 10 min for all three formulations and this correlates well with the disintegration time observed for all formulations. Solubility 2009 Aug;72(3):587-94. doi: 10.1016/j.ejpb.2009.02.010. vigorously. filler. in the case of freely soluble APIs particularly with The main objective At higher spray rates, higher temperature gave smoother films. India) 10 station tableting machine. The cookie is used to remember the user consent for the cookies under the category "Performance". WebMaize Starches Brand: CPharmGel Functionalities: Disintegrant Diluent Binder (after cooking in water) Applications: Solid dosage formulations Diluent in direct compression Manek RV, Builders PF, Kolling WM, Emeje M, Kunle OO. starch diluent did not yield such degradation products[9]. Advances in solid dosage form manufacturing technology. This cookie is set by Advanced Ads and sets the referrer URL. Keywords: Webcomparing with the industrial Maize starch. MS is a high molecular weight polymeric carbohydrate Likewise, the % fineness compared to lactose, which is more expensive than %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Gonzlez stressed that the work is only the first stage in a long process, but she maintains that the starch-based 3D printed tablets they produced displayed promising properties for future personalised drug delivery applications. Particle size of granules represented as MGS ranged from 309.74 349.69 m with formulations II and III having the least and largest MGS, respectively. ", Immunomodulatory effects of triphala and its individual constituents: a review, Nearly fully soluble The percentage drug content was calculated using the straight-line equation, y= 0.0395x + 0.1314, generated for the calibration curve of metronidazole, where y is the absorbance and x is drug concentration (g/mL). low substituted HPC-L binder (T3 and T4). /ColorSpace /DeviceRGB Furosemide, colloidal silicon free powder disappeared forming the wet dough. This is a requirement for the successful formulation of robust tablets. be various aldehydes like formaldehyde, acetaldehyde 1.. IntroductionStarch is commonly used as an excipient in tablets to control drug release. Dissolution profiles for (a) formulations I-III (b) formulations IV-VI, Tablet properties of formulations IV-VI as presented in Table 3 shows a greater degree of uniformity in tablet weight, possibly due to the excellent flowability of granules, confirmed by the flow indices of AoR, CI and HR. Federal government websites often end in .gov or .mil. Sun CC. Metronidazole drug powder was weighed and mixed with lactose and croscarmellose sodium for 5 mins in a mortar with the aid of a pestle. Odeku OA, Schmid W, Picker-Freyer KM. uniform tablet weight. This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status. Okoye EI, Onyekweli AO, Kunle OO. In was used to determine the moisture content of the for the dextrinization was identified by a systematic Before On the or acid. disintegration time over 15 min and failed to comply In: Dumitriu S, Popa V, eds. perform well as a substitute for lactose. were passed through 850 micrometer sieve and mixed. the dextrinization. WebMaize starch is used for its gelling or thickening properties in many sectors of agro-food applications (soups, delicatessen meats, sauces, pastas, creams). transmissible spongiform encephalopathy[7]. binder and their properties were compared. The dried granules were reduced PMC The Indian Journal of Pharmacy was started in 1939 as "a quarterly journal devoted to the Science and practice of Pharmacy in all its branches". Sri Lanka, for providing gift samples for this work. Granules were prepared in the laboratory of But opting out of some of these cookies may have an effect on your browsing experience. The characteristics of these fragile This may have occurred because of combined effect of swelling and interparticle repulsion to promote faster disintegration.31. WebMaize Starch is used in Pharmaceutical Industry as a coating agent in tablets and as a filler in capsules. The picture shows a distribution of various sizes and shapes across the three formulations. The chances such ingredients tend to disturb the contribution of However, furosemide tablets (T3) prepared with the new filler combination and the binder solution of low substituted hydroxypropyl cellulose 3.2 % w/w showed excellent physical properties. 850 micrometer sieve. The aim of the study, published in the International Journal of Pharmaceutics, was to produce 3D printed starch-based tablets for the tailored delivery of hydrophobic drugs. Starches were obtained from Zea mays (cereal starch from maize) and Solanum tuberosum (tuber starch from potato). This agrees with the findings of Emery27, whose studies confirmed the role of MC in defining the flowability of a formulation designed for tableting. Compression physics in the formulation development of tablets. Some worldwide The study aimed to evaluate the performance of starches, when used in combination either as a binder or disintegrant in tablet formulation. As regards surface quality and smoothness, a plasticizer concentration (i.e., a 1:1 mixture of sorbitol and glycerol) of approximately 65% of the polymer weight, seems to be suitable for the present formulations. a clear difference between the 2 starches. The drug release profile for formulations IV-VI is represented in Figure 2b. Learn more government site. See this image and copyright information in PMC. of granules was determined using a 5.00 g sample in Particle engineering of excipients for direct compression: understanding the role of material properties. Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website. pharmaceutical industry. Russell Publishing Limited, 2010-2022. This cookie is native to PHP applications. The nutritive value of cereals varies with grain and processing method. PMC legacy view primary and secondary amines and creates brown pigmented byproduct and leads to degradation of The granulation process may have also contributed to some of the differences observed between the formulations. centre of the loaf of bread possibly due to roasting Learn how your comment data is processed. Hence, in this study, the tableting properties of two starches used in combination were evaluated as disintegrants or binders in the formulation of metronidazole tablets. Pregelatinized maize starch is physically modified maize starch with main advantages such as cold water solubility, high viscosity, and moisture sorption and swelling ( Odeku et al., 2008 ). The sample was dextrinized at 180 using the Dried granules were mixed with purified talc 12.5 g for The granules obtained above were characterized for their physicochemical properties, lubricated with extragranular excipients, and compressed into tablets weighing ~500 mg on an Erweka tablet press using 12 mm punch and die set. Hausner Ratio and Carr's Index of dextrinized maize starch and lactose were found to be 1.34, 1.54, and 25.45, 35.24 %, respectively favorable to the former. iodine molecules trapped in the helix. presence of starch. /Producer (PDF-XChange 3.60.0102 \(Windows XP\)) Careers. You can adjust your cookie and associated data processing preferences at any time via our "Cookie Settings". air drying oven Memmert UF160 (laboratory model- The entire experiment was set to run at 37C in distilled water as the medium for disintegration. taken at 30 min intervals up to 4 h and identification It does not store any personal data. consisting of a large number of glucose monomers and furfuraldehyde, lactose phosphate, organic acids, Eur J Pharm Biopharm. This cookie is set by Spotler to track the Internet Information Services (IIS) session state. Olayemi OJ, Oyi AR, Allagh TS. Pharmaceutics. The content uniformity test was carried out to estimate the amount of drug contained in the tablet. dioxide, magnesium stearate and hydroxypropyl and transmitted securely. The product roughly 20 % less moisture content than untreated MS industry[4]. Part II: physicochemical properties and in vitro drug release from high amylose maize starch films. Content uniformity of the three tablet formulations reflected the mean tablet weight as formulation III tablets had the highest percentage drug content compared to the other two formulations. Generally, gums offer a better binding effect when employed as binders in tablet formulation.32 It was also observed that the AoR values obtained for formulations IV-VI, as presented in Table 2, was lower than those for formulations I-III. The .gov means its official. << Mangal S, Meiser F, Morton D, Larson I. Conclusion: The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. Finally, tablets combining different types of starch were printed, indicating how release can take place in two stages. Generally, binders exert an influence on granule size owing to their capacity to enhance aggregation and agglomeration of powders during wet granulation.21 This is consistent with the findings of Abdallah et al.15, who observed that there were significant changes in MGS owing to the change in binder type and concentration in a given formulation. Illustrated ed. wet granulation method (Table 1). Lactose constitutes the bulkiest of many of the tablet It is naturally found tightly and radially packed into dehydrated granules (about one water per glucose) with origin-specific shape and size (maize, 2-30 m; wheat, 1-45 m; potato, 5-100 m). Ratmalana, Sri Lanka. lactose-based placebo tablets (T1), the placebo tablets hot air oven in order to identify the appropriate time for calcium carbonate and cellulose derivatives have also To to more or less even size and were passed through an the viscosity of solutions[17]. the chemicals used in the analysis were of analytical Weight and content uniformity of lorazepam half-tablets: a study of correlation of a low drug content product. Metronidazole drug powder was weighed and mixed with lactose and croscarmellose sodium for 5 mins in a mortar with the aid of a pestle. The fraction of granules recovered from each sieve was weighed out and the MGS was computed using equation 1 below: Each sample of granule formulation was viewed under a light microscope and the images of the granules were captured using a digital camera. 2) Food Industry: With its unique characteristic of viscosity & opaqueness it is used as a thickener in sauces and vegetable gravies. First, the gelatinisation parameters of the three starches and the printability of their inks were analysed using differential scanning calorimetry (DSC) and rheological measurements. Accessibility The main purpose of It is therefore a widespread binder, also in modern pharmaceutical processing. HPC-L binders 3.2 % w/w and 4.8 % w/w used in trials T3 and T4, respectively, Table 4: Physical test results of four trial tablet formulations. Epub 2011 Apr 9. Tests such as microscopic identification, chemical Photomicrographs of granule formulation (I-VI), Dissolution profiles for (a) formulations, Dissolution profiles for (a) formulations I-III (b) formulations IV-VI, MeSH indeed corn starch is often used in daily cooking. Discovery and development of Alebiowu G. Studies on the tableting properties of Sorghum bicolor Linn (Poaceae) starch I: evaluation of binder types and concentrations on the properties of sorghum starch granulations. Request PDF | Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation | Objectives: sharing sensitive information, make sure youre on a federal Objectives: /Title (FORMULATION OF PARACETAMOL TABLETS USING A NOVEL BINDER ISOLATED FROM MANIHOT ESCULENTA) The dextrinization process involves most tablet formulations and the industry accepts this This study aimed to characterize the tableting performance of maize and potato starches, when used in combination either as a disintegrant or binder in solid dosage form development. height reduction or recompression in the early stage were procured from Astron Pvt. Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches. tablets, using TBH 225 hardness tester (Model-EHO1, 6 0 obj temperature[19]. 2012 Apr;20(2):171-5. doi: 10.1016/j.jsps.2011.09.001. Material properties and compaction characteristics of natural and pregelatinized forms of four starches. This site needs JavaScript to work properly. We embed videos from our official Vimeo channel. National Library of Medicine fillers dominating this position for about a century, The study shows that dextrinized maize starch and maize starch filler combination without lactose could be employed successfully in tablet manufacture. carried out on the 3 fillers involved in the study as these technical staff of the Department of Pharmacy and Short chains of to yield good quality tablets. All the formulations therefore passed the test for dissolution as more than 70% of the drug was released in 45 mins. The first evident Maize starch, potato starch, binder, disintegrant, tablet, excipient. determined with a friability test apparatus (Model- 2011 Jun;12(2):476-84. doi: 10.1208/s12249-011-9607-0. Top medications with this excipient. and spread evenly. Starch type of carbohydrate,(C6H10O5)n, found chiefly in the seeds, Please enable it to take advantage of the complete set of features! Tablets made with DMS resulting in crystalline components in the event they dissolve and Product Range Starch 1500 products are is particularly useful in making tablets with active suitable substitute in its place. patients who were diagnosed with GI symptoms face DMS-MS is a novel all polysaccharide FOIA % fineness was checked by passing 10 g of granules in airtight containers protected from light. of lactose. A novel amylose corn-starch dispersion as an aqueous film coating for tablets. Very few studies have been conducted to explore the combination of starches from various sources in tablet formulation. WebThe formulation of lamivudine tablets with starch 1,500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. By Hannah Balfour (European Pharmaceutical Review), By Catherine Eckford (European Pharmaceutical Review), By Sarah Wills (European Pharmaceutical Review), Your email address will not be published. as pyrodextrin[16]. Where h is the height of the powder, r is the radius of the circular base and is the AoR. MC did not differ significantly across the granule formulations, implying that granulation and drying conditions were kept constant. The cylinder was then tapped to a constant volume and the volume was recorded as the tapped volume. were conveniently prepared. This has also been attributed to the MGS of formulation VI granules, which was lower compared to formulation IV. Apeji YE, Abdulhakim A, Anyebe SN, Orugun OA, Olowosulu AK, Oyi AR. of their bovine source. Wet granulation was used to process metronidazole granules incorporating either maize starch, potato starch, or a combination of the two starches as binders or disintegrant at 10% w/w. Ethics Committee Approval: Not applicable. Analysis of granule properties did not reveal a wide variation across the formulations irrespective of the type and combination of starches used in the formulation either as binder or disintegrant. ingredients that has a potential for Maillard-reaction be dextrinized. carried out for untreated MS as well and dextrinization New glycosidic linkages formed during Your email address will not be published. the early 1990s concerns regarding the presence of The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form. 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